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pbpk software v21  (Simcyp)

 
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    Simcyp pbpk software v21
    Pbpk Software V21, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pbpk software v21/product/Simcyp
    Average 90 stars, based on 1 article reviews
    pbpk software v21 - by Bioz Stars, 2026-05
    90/100 stars

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    Image Search Results


    Prediction results of candesartan American intravenous PBPK model.

    Journal: Pharmaceuticals

    Article Title: From In Vivo Predictive Dissolution to Virtual Bioequivalence: A GastroPlus ® -Driven Framework for Generic Candesartan Cilexetil Tablets

    doi: 10.3390/ph18040562

    Figure Lengend Snippet: Prediction results of candesartan American intravenous PBPK model.

    Article Snippet: The PBPK model of candesartan cilexetil was developed using commercially available PBPK modeling software GastroPlus ® (version 9.5, Simulations Plus, Inc., Lancaster, CA, USA) and Digit literature data extraction software (version 1.0.4, Simulation Plus, Inc., Lancaster, CA, USA).

    Techniques:

    PBPK model predictions of 8 mg candesartan cilexetil tablets administered via preprandial oral route across ethnic populations. ( A ) Japanese and ( B ) Chinese.

    Journal: Pharmaceuticals

    Article Title: From In Vivo Predictive Dissolution to Virtual Bioequivalence: A GastroPlus ® -Driven Framework for Generic Candesartan Cilexetil Tablets

    doi: 10.3390/ph18040562

    Figure Lengend Snippet: PBPK model predictions of 8 mg candesartan cilexetil tablets administered via preprandial oral route across ethnic populations. ( A ) Japanese and ( B ) Chinese.

    Article Snippet: The PBPK model of candesartan cilexetil was developed using commercially available PBPK modeling software GastroPlus ® (version 9.5, Simulations Plus, Inc., Lancaster, CA, USA) and Digit literature data extraction software (version 1.0.4, Simulation Plus, Inc., Lancaster, CA, USA).

    Techniques:

    PBPK-model-predicted pharmacokinetic profiles of 8 mg candesartan cilexetil tablets following fasted oral administration in Chinese.

    Journal: Pharmaceuticals

    Article Title: From In Vivo Predictive Dissolution to Virtual Bioequivalence: A GastroPlus ® -Driven Framework for Generic Candesartan Cilexetil Tablets

    doi: 10.3390/ph18040562

    Figure Lengend Snippet: PBPK-model-predicted pharmacokinetic profiles of 8 mg candesartan cilexetil tablets following fasted oral administration in Chinese.

    Article Snippet: The PBPK model of candesartan cilexetil was developed using commercially available PBPK modeling software GastroPlus ® (version 9.5, Simulations Plus, Inc., Lancaster, CA, USA) and Digit literature data extraction software (version 1.0.4, Simulation Plus, Inc., Lancaster, CA, USA).

    Techniques:

    Model simulations of vancomycin concentration-time profiles from four studies in the training dataset: (A) Observed and PBPK model simulated vancomycin plasma concentrations after a single 1,000 mg intravenous dose in a young US population. (B) Observed and PBPK model simulated vancomycin plasma concentrations after a single 1,000 mg intravenous dose in a young Chinese population. (C) Observed and PBPK model simulated vancomycin plasma concentrations after multiple 1,000 mg doses every 12 h in the HC group. (D) Observed and PBPK model simulated vancomycin plasma concentrations after multiple 1,000 mg doses every 12 h in the LC group.

    Journal: Frontiers in Pharmacology

    Article Title: High vs. low vancomycin therapeutic concentrations in periprosthetic joint infection: A retrospective cohort analysis

    doi: 10.3389/fphar.2025.1555276

    Figure Lengend Snippet: Model simulations of vancomycin concentration-time profiles from four studies in the training dataset: (A) Observed and PBPK model simulated vancomycin plasma concentrations after a single 1,000 mg intravenous dose in a young US population. (B) Observed and PBPK model simulated vancomycin plasma concentrations after a single 1,000 mg intravenous dose in a young Chinese population. (C) Observed and PBPK model simulated vancomycin plasma concentrations after multiple 1,000 mg doses every 12 h in the HC group. (D) Observed and PBPK model simulated vancomycin plasma concentrations after multiple 1,000 mg doses every 12 h in the LC group.

    Article Snippet: To assess pharmacokinetics and tissue distribution of vancomycin in PJI patients, we employed the commercially available dynamic PBPK modeling software GastroPlusTM version 9.9 (Simulations Plus, Inc.) to construct a stepwise model as previously described ( ).

    Techniques: Concentration Assay, Clinical Proteomics

    The model to predict vancomycin concentrations in the red marrow, yellow marrow and kidney: (A) Observed and PBPK model simulated concentrations in plasma, red marrow, and yellow marrow in the HC group. (B) Observed and PBPK model simulated concentrations in plasma, red marrow, and yellow marrow in the LC group. (C) Observed and PBPK model simulated concentrations in plasma and kidney in the HC group. (D) Observed and PBPK model simulated concentrations in plasma and kidney in the LC group.

    Journal: Frontiers in Pharmacology

    Article Title: High vs. low vancomycin therapeutic concentrations in periprosthetic joint infection: A retrospective cohort analysis

    doi: 10.3389/fphar.2025.1555276

    Figure Lengend Snippet: The model to predict vancomycin concentrations in the red marrow, yellow marrow and kidney: (A) Observed and PBPK model simulated concentrations in plasma, red marrow, and yellow marrow in the HC group. (B) Observed and PBPK model simulated concentrations in plasma, red marrow, and yellow marrow in the LC group. (C) Observed and PBPK model simulated concentrations in plasma and kidney in the HC group. (D) Observed and PBPK model simulated concentrations in plasma and kidney in the LC group.

    Article Snippet: To assess pharmacokinetics and tissue distribution of vancomycin in PJI patients, we employed the commercially available dynamic PBPK modeling software GastroPlusTM version 9.9 (Simulations Plus, Inc.) to construct a stepwise model as previously described ( ).

    Techniques: Clinical Proteomics